Dysbiosis can permit growth of C. diff.1 Antibiotics treat C. diff but may worsen the dysbiosis and lead to recurrence.2,3
Restoring the microbiome to its diverse microbial composition helps inhibit C. diff and thus can prevent recurrence.2,4
C. diff and its recurrence can lead to significant complications for patients and burden healthcare systems.5,6
Bien J, Palagani V, Bozko P. The intestinal microbiota dysbiosis and Clostridium difficile infection: is there a relationship with inflammatory bowel disease? Therap Adv Gastroenterol. 2013;6(1):53-68.
Seekatz AM, Safdar N, Khanna S. The role of the gut microbiome in colonization resistance and recurrent Clostridioides difficile infection. Therap Adv Gastroenterol. 2022;15:1-18.
DePestel DD, Aronoff DM. Epidemiology of Clostridium difficile infection. J Pharm Pract. 2013;26(5):464-475.
Khanna S. Microbiota restoration for recurrent Clostridioides difficile: Getting one step closer every day! J Intern Med. 2021;290(2):294-309.
Feuerstadt P, Boules M, Stong L, et al. Clinical complications in patients with primary and recurrent Clostridioides difficile infection: a real-world data analysis. SAGE Open Med. 2021;14(9):1-8.
Feuerstadt P, Theriault N, Tillotson G. The burden of CDI in the United States: a multifactorial challenge. BMC Infect Dise. 2023;23:132.
